Learning Insulin-Glucose Dynamics in the Wild
AuthorsAndrew C. Miller, Nicholas J. Foti, Emily Fox
AuthorsAndrew C. Miller, Nicholas J. Foti, Emily Fox
We develop a new model of insulin-glucose dynamics for forecasting blood glucose in type 1 diabetics. We augment an existing biomedical model by introducing time-varying dynamics driven by a machine learning sequence model. Our model maintains a physiologically plausible inductive bias and clinically interpretable parameters — e.g., insulin sensitivity — while inheriting the flexibility of modern pattern recognition algorithms. Critical to modeling success are the flexible, but structured representations of subject variability with a sequence model. In contrast, less constrained models like the LSTM fail to provide reliable or physiologically plausible forecasts. We conduct an extensive empirical study. We show that allowing biomedical model dynamics to vary in time improves forecasting at long time horizons, up to six hours, and produces forecasts consistent with the physiological effects of insulin and carbohydrates.
October 28, 2024research area Methods and Algorithmsconference NeurIPS
Many healthcare applications are inherently multimodal, involving several physiological signals. As sensors for these signals become more common, improving machine learning methods for multimodal healthcare data is crucial. Pretraining foundation models is a promising avenue for success. However, methods for developing foundation models in healthcare are still in early exploration and it is unclear which pretraining strategies are most effective...
October 24, 2022research area Health, research area Methods and Algorithmsconference ML for Healthcare
Increased use of sensor signals from wearable devices as rich sources of physiological data has sparked growing interest in developing health monitoring systems to identify changes in an individual’s health profile. Indeed, machine learning models for sensor signals have enabled a diverse range of healthcare related applications including early detection of abnormalities, fertility tracking, and adverse drug effect prediction. However, these...